Opis stanowiska

A position for a PhD candidate is open for a highly motivated person to join our research group at Department of Cell Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, Poland. The successful candidate will participate in a project which is focused on mechanisms of DNA damage induction and repair in mammalian oocytes and somatic cells. Cell biology and biophysical techniques will be used, including fluorescence confocal and super-resolution imaging, and various methods of detection of DNA damage and repair.

The overall goal of the proposal is to improve our understanding of the mechanisms behind a lower mutation rate of the female germline in comparison with somatic cells. The planned research involves direct measurements the numbers of endogenous single-strand DNA breaks (STRIDE technique, Nucl. Acids Res. 2020), measurements and imaging of localisation of critical SSB repair factors in oocytes and somatic cells, assessing the capacity of oocytes and zygotes to repair SSBs, and measurements of abundance of repair components and assessing their role in conferring resistance to DNA damage.

Application documents (required as part of a given PhD study programme and resulting from the specificity of the research project) :

· Curriculum vitae

Please send your application documents to the project manager, prof. dr hab. Jerzy Dobrucki at: jerzy.dobrucki@uj.edu.pl, and upload them into the Online Application System (irk.uj.edu.pl).

The ideal candidate should fulfil the following criteria:

· Have basic knowledge about cell biology and biophysics

· Have command of spoken and written English

More information about the Cell Biophysics Department is available at: https://helios.wbbib.uj.edu.pl/en_GB/home

Official announcement: https://science.phd.uj.edu.pl/en_GB/rekrutacja/konkursy_otwarte/-/journal_content/56_INSTANCE_RDlx0DYCtObf/142594442/150069670