Opis stanowiska
OFFER DESCRIPTION
A postdoctoral position is open for a highly motivated person with experience in cell biology and/or biophysics, to join our research group at Department of Cell Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, Poland. The successful candidate will participate in a project which is focused on mechanisms of DNA damage induction and repair in mammalian oocytes and somatic cells. Cell biology and biophysical techniques will be used, including fluorescence confocal and super-resolution imaging, and various methods of detection of DNA damage and repair.
The overall goal of the proposal is to improve our understanding of the mechanisms behind a lower mutation rate of the female germline in comparison with somatic cells. The planned research involves direct measurements the numbers of endogenous single-strand DNA breaks (sSTRIDE technique, Nucl. Acids Res. 48(3), 2020, p. e14), measurements and imaging of localisation of critical SSB repair factors in oocytes and somatic cells, assessing the capacity of oocytes and zygotes to repair SSBs, and measurements of abundance of repair components and assessing their role in conferring resistance to DNA damage.
Jagiellonian University ranks among the best and the oldest (est. 1364) universities in Europe. Faculty of Biochemistry, Biophysics and Biotechnology offers state-of-the-art equipment and technological facilities, and ample collaboration opportunities with other research groups on the campus, in all disciplines of science. More information:
Jagiellonian University: https://en.uj.edu.pl/en_GB/start
Faculty of Biochemistry, Biophysics and Biotechnology: https://wbbib.uj.edu.pl/en_GB/start-en
Department of Cell Biophysics: https://helios.wbbib.uj.edu.pl/
Kraków is a vibrant city, one of the most visited tourist destinations in Europe, and a renowned centre of science and technology. For more information visit: https://www.lonelyplanet.com/poland/malopolska/krakow
FUNDING ORGANISATION
The project is funded by National Science Center, Poland, and Czech Science Foundation, Czech Republic.
Eligibility criteria
Educational level: Applicants must have a Ph.D. or equivalent (biological sciences or physics)
Required languages: Good command of spoken and written English.
LABORATORY EXPERIENCE AND METHODS
Hands-on experience with fluorescence confocal imaging, in vitro cell cultures, immunofluorescence, methods of detection of DNA damage and repair, western blots, plasmid multiplication will constitute an advantage.
APPLICATION PROCEDURE
Required Application Materials:
1. Cover letter, including description of research interests
2. Curriculum vitae
3. Copies (pdf) of first author publications
4. Names and contact information for at least two referees
The candidates who fulfil the criteria of the job announcement will be invited for an interview (Zoom, Skype).
APPOINTMENT:
Appointment starting date: position open immediately
Appointment term: three years
Info about the lab: https://helios.wbbib.uj.edu.pl/en_GB/
Inquiries: jerzy.dobrucki@uj.edu.pl
Application deadline: 30 November 2022
Interested candidates should send the application documents by e-mail to: jerzy.dobrucki@uj.edu.pl